Opaleye Management Inc. and Affiliates File Schedule 13G for Sol-Gel Technologies Ltd

Opaleye Management Inc., Opaleye, L.P., and James Silverman have jointly filed a Schedule 13G with the SEC, disclosing beneficial ownership of 139,386 ordinary shares of Sol-Gel Technologies Ltd, representing 5.00% of the outstanding shares. The filing is made pursuant to Rule 13d-1(c) of the Securities Exchange Act of 1934. Opaleye Management Inc. serves as the investment adviser to Opaleye, L.P., and James Silverman exercises control over the Adviser. The shares are held directly by Opaleye, L.P., and the filing is not intended to influence the control of the issuer. The joint filing agreement, dated August 29, 2025, is included as an exhibit.