Amendment to Market Purchase Agreement with Alumni Capital LP

RedHill Biopharma Ltd. has entered into an amendment to its Any Market Purchase Agreement with Alumni Capital LP, originally signed on June 20, 2025. The amendment increases the ownership limit from 4.99% to 9.99% for Forward Purchase Notices, allowing the Company to sell up to $10,000,000 of American Depositary Shares (ADSs) to Alumni Capital LP. The ADSs represent ordinary shares of the Company, and the amendment specifies the terms and conditions for these transactions. The amendment does not affect other provisions of the original agreement, which remain in full force and effect. This change is intended to provide the Company with greater flexibility in managing its equity financing.