Power of Attorney for Katina Dorton at Prelude Therapeutics Inc

Katina Dorton, a director of Prelude Therapeutics Inc, has executed a Power of Attorney document. This document appoints the company's Chief Executive Officer, Chief Financial Officer, and Chief Legal Officer as her attorneys-in-fact. They are authorized to execute and file Form ID, Form 3, Form 4, and Form 5 reports on her behalf as required by Section 16(a) of the Securities Exchange Act of 1934. The attorneys-in-fact are also empowered to perform any necessary acts related to these filings and to take any other actions deemed beneficial or legally required. The Power of Attorney remains in effect until Dorton is no longer required to file these reports or until she revokes it in writing. The document was signed on October 14, 2025.