Perceptive Advisors LLC and Joseph Edelman Report 9.99% Ownership in Palisade Bio, Inc.

Perceptive Advisors LLC, Joseph Edelman, and Perceptive Life Sciences Master Fund, Ltd. have filed a Schedule 13G reporting a 9.99% beneficial ownership in Palisade Bio, Inc. The filing indicates that the Master Fund directly holds 12,050,000 shares of Common Stock and 5,185,714 Pre-Funded Warrants, which are immediately exercisable for shares of Common Stock at an exercise price of $0.0001 per share. However, the Pre-Funded Warrants are subject to a Beneficial Ownership Limitation, which restricts the Reporting Persons from exercising the warrants if it would result in them owning more than 9.99% of the outstanding shares. Perceptive Advisors serves as the investment manager to the Master Fund, and Joseph Edelman is the managing member of Perceptive Advisors. The filing was made pursuant to Rule 13d-1(c) and was signed on October 9, 2025.