Amendment No. 2 to Schedule 13D for KALA BIO, Inc.

This Amendment No. 2 to Schedule 13D, filed by Baker Bros. Advisors LP and related entities, reports the sale of common stock of KALA BIO, Inc. that resulted in a more than 1 percent change in beneficial ownership. The amendment also details the conversion rights of Series E, F, G, and H Preferred Stock into Common Stock, subject to a 9.99% beneficial ownership limitation. The Reporting Persons may acquire or dispose of additional securities based on various factors, including market conditions and the Issuer's business prospects. The filing includes transactions in Common Stock effected by the Funds in the 60 days preceding the statement.