Power of Attorney for David R. Knox

The filing is a Power of Attorney document for David R. Knox, the Chief Financial Officer of Hyperion DeFi, Inc. The document confirms that Knox's electronic signature can be used to authenticate, acknowledge, or adopt his signature in any document electronically filed with or furnished to the SEC by him or on his behalf, or by Hyperion DeFi, Inc. This electronic signature will be legally equivalent to his manual signature. The document also states that a copy will be provided to the SEC or its staff upon request. The filing is dated October 1, 2025.