Accardi Mario Alberto's Transactions in Centessa Pharmaceuticals plc Shares

On October 27, 2025, Accardi Mario Alberto, President of the Orexin Program at Centessa Pharmaceuticals plc, engaged in several transactions involving the company's Ordinary Shares. He acquired 5,000 shares at $8.01 per share and disposed of 8,000 shares at $25.00 per share. The sales were executed under a Rule 10b5-1 trading plan adopted on February 14, 2025. Additionally, he disposed of 5,000 share options (right to buy) with an exercise price of $8.01 per share, which are set to expire on February 1, 2034. Following these transactions, Alberto owns 194,394 Ordinary Shares and 30,000 share options.