Amendment to Schedule 13G Filing for Crescent Biopharma, Inc.

This filing is an amendment to the Schedule 13G for Crescent Biopharma, Inc., submitted by 1Globe Capital LLC and Jiaqiang Li. The amendment updates the beneficial ownership details of the reporting persons. 1Globe Capital LLC and Jiaqiang Li each report a 10.3% ownership of the ordinary shares of Crescent Biopharma, Inc., based on 13,892,562 shares outstanding as of July 25, 2025. The shares are held with shared voting and dispositive power. Jiaqiang Li, who serves as the Chairman of 1Globe Capital LLC, may be deemed the ultimate beneficial owner of these shares. Both reporting persons disclaim beneficial ownership of securities not directly owned by them, except to the extent of their pecuniary interest. The filing is made pursuant to Rule 13d-1(c) and includes certifications that the securities were not acquired for the purpose of influencing the control of the issuer.