Initial Statement of Beneficial Ownership

This filing reports that Knight Therapeutics Inc. now directly owns 658,629 shares of common stock in 60 Degrees Pharmaceuticals, Inc. This represents a significant ownership stake, with Knight Therapeutics Inc. being identified as a ten percent owner. The transaction date was July 22, 2026. The filing was made on July 28, 2026, and signed by Samira Sakhia, President and Chief Executive Officer of Knight Therapeutics Inc.