Power of Attorney for Section 16 Reporting Obligations

This filing is an exhibit, specifically a Limited Power of Attorney, for Section 16 Reporting Obligations. It designates Alex Sapir, Curt Oltmans, and Alan Musso as attorneys-in-fact for Joshua Lehrer-Graiwer, a director of Fulcrum Therapeutics, Inc. The attorneys-in-fact are authorized to execute and file all necessary Forms 3, 4, and 5 with the SEC and any stock exchange on behalf of Mr. Lehrer-Graiwer. They are also empowered to obtain information about transactions in the Company's securities from third parties and to take any other actions deemed beneficial or legally required. This power of attorney remains in effect until Mr. Lehrer-Graiwer is no longer required to file such forms, or until earlier revoked. The filing clarifies that neither the attorneys-in-fact nor the Company assume liability for Mr. Lehrer-Graiwer's compliance with Section 16 of the Exchange Act.