Amendment to Schedule 13D for Design Therapeutics, Inc.

This filing is an amendment to a previously filed Schedule 13D, reporting a decrease in beneficial ownership of Design Therapeutics, Inc. common stock by SR One Capital Fund I Aggregator LP and related entities. The decrease is attributed to an increase in the total number of outstanding shares of common stock. SR One Capital Fund I Aggregator LP, along with SR One Capital Partners I, LP, SR One Capital Management, LLC, and Simeon George, M.D., are the reporting persons. As of March 2, 2026, there were 61,672,279 shares of common stock outstanding. SR One Capital Fund I Aggregator LP beneficially owns 6,526,476 shares, representing 10.6% of the outstanding shares. Simeon George, M.D. beneficially owns 6,607,892 shares, representing 10.7% of the outstanding shares. No transactions in the company's stock were effected by the reporting persons in the last 60 days.