Form 4 Filing for AstraZeneca PLC

Mani Sharma, SVP, Group Controller and Head of Global Finance Services at AstraZeneca PLC, acquired 1 ordinary share on June 8, 2026, at a price of $179.75 per share. This acquisition was made under the Issuer's Share Incentive Plan. The transaction price, originally in GBP, was converted to USD using a rate of GBP1.0000 to $1.3360 on June 5, 2026. Following this transaction, Sharma holds 19,263.4659 shares. The filing is Form 4, indicating a change in beneficial ownership.