Director/PDMR Shareholding Filing

This filing reports a transaction by Michel Demaré, Non-Executive Chair of the Board of AstraZeneca PLC. On September 14, 2026, Mr. Demaré purchased 2,500 ordinary shares of the company at a price of GB£121.21 per share. The notification was made in accordance with the EU Market Abuse Regulation. AstraZeneca PLC is a global, science-led biopharmaceutical company focused on discovery, development, and commercialization of prescription medicines.