Sponsored

The Analysis of RTW INVESTMENTS, LP's Holdings & P&L

Currently, RTW INVESTMENTS, LP holds 98 types of securities in its portfolio with a total value $10.2B. In the most recent quarter, they have increased their positions in INSM (+1.8M shares, valued at $306.0M), IRTC (+1.2M shares, valued at $209.7M), APLS (+7.7M shares, valued at $192.6M); decreased their positions in NTRA (-500.0K shares, valued at $114.5M), SYK (-245.0K shares, valued at $86.1M), PTGX (-697.2K shares, valued at $60.9M); initiated new positions in IRTC (+1.2M shares, valued at $209.7M), APLS (+7.7M shares, valued at $192.6M), RGEN (+1.1M shares, valued at $174.3M).

1M P&L

-3.9M-0.04%

3M P&L

+198.9M+2.13%

HY P&L

+692.8M+7.82%

P&L figures are estimated based on reported 13F stock holdings and market price changes. They are approximations and may not reflect actual fund performance. Stock split events may also affect the accuracy of these calculations, and we cannot guarantee that all splits have been fully accounted for.

Top Holding Treemap

Top Industries by Value

1Biotechnology7.5B

75.1%

2Medical Devices1.0B

10.1%

3Diagnostics & Research891.9M

8.9%

Top Industries by Stock Count

1Biotechnology62 stocks

70.5%

2Medical Devices7 stocks

8.0%

3Diagnostics & Research7 stocks

8.0%

Sponsored

Stock Holdings

TickerCompany NameSharesShares △%Event DateReport DateHistory

MDGL MADRIGAL PHARMACEUTICALS INC2.0M shares0.00%2025-12-312026-02-17

INSM INSMED INC4.8M shares57.00%2025-12-312026-02-17

PTCT PTC THERAPEUTICS INC7.7M shares0.00%2025-12-312026-02-17

ARGX ARGENX SE673.5K shares0.00%2025-12-312026-02-17

PTGX PROTAGONIST THERAPEUTICS INC5.1M shares-12.11%2025-12-312026-02-17

NTRA NATERA INC1.5M shares-25.00%2025-12-312026-02-17

RDNT RADNET INC3.9M shares39.88%2025-12-312026-02-17

TARS TARSUS PHARMACEUTICALS INC3.3M shares4.97%2025-12-312026-02-17

Sponsored

COGT COGENT BIOSCIENCES INC7.6M shares118.96%2025-12-312026-02-17

PEN PENUMBRA INC866.5K shares0.00%2025-12-312026-02-17

IRTC IRHYTHM TECHNOLOGIES INC1.2M sharesnew addition2025-12-312026-02-17

APGE APOGEE THERAPEUTICS INC2.7M shares0.00%2025-12-312026-02-17

APLS APELLIS PHARMACEUTICALS INC7.7M sharesnew addition2025-12-312026-02-17

ACAD ACADIA PHARMACEUTICALS INC7.1M shares0.00%2025-12-312026-02-17

ESTA ESTABLISHMENT LABS HLDGS INC2.6M shares0.00%2025-12-312026-02-17

STOK STOKE THERAPEUTICS INC5.5M shares8.26%2025-12-312026-02-17

Sponsored

RGEN REPLIGEN CORP1.1M sharesnew addition2025-12-312026-02-17

CYTK CYTOKINETICS INC2.7M shares0.00%2025-12-312026-02-17

IMCR IMMUNOCORE HLDGS PLC4.9M shares0.00%2025-12-312026-02-17

AXSM AXSOME THERAPEUTICS INC888.0K shares-20.64%2025-12-312026-02-17

GH GUARDANT HEALTH INC1.5M shares0.00%2025-12-312026-02-17

NBIX NEUROCRINE BIOSCIENCES INC1.1M shares0.00%2025-12-312026-02-17

SYRE SPYRE THERAPEUTICS INC4.2M shares15.18%2025-12-312026-02-17

ZLAB ZAI LAB LTD7.0M shares203.71%2025-12-312026-02-17

Sponsored

IMTX IMMATICS N.V11.4M shares29.69%2025-12-312026-02-17

BLTE BELITE BIO INC715.3K shares128.91%2025-12-312026-02-17

URGN UROGEN PHARMA LTD4.5M shares0.00%2025-12-312026-02-17

XNCR XENCOR INC6.8M shares8.94%2025-12-312026-02-17

RAPT 1.6M sharesnew addition2025-12-312026-02-17

PODD INSULET CORP324.6K sharesnew addition2025-12-312026-02-17

TSHA TAYSHA GENE THERAPIES INC16.4M shares-32.67%2025-12-312026-02-17

MASI MASIMO CORP683.3K shares0.00%2025-12-312026-02-17

Sponsored

QURE UNIQURE NV3.7M shares-16.12%2025-12-312026-02-17

SYK STRYKER CORPORATION245.0K shares-50.00%2025-12-312026-02-17

CGON CG ONCOLOGY INC2.0M shares18.28%2025-12-312026-02-17

CSTL CASTLE BIOSCIENCES INC2.1M sharesnew addition2025-12-312026-02-17

IMVT IMMUNOVANT INC3.2M sharesnew addition2025-12-312026-02-17

BBNX BETA BIONICS INC2.5M shares-24.22%2025-12-312026-02-17

GHRS GH RESEARCH PLC5.9M shares6.54%2025-12-312026-02-17

REPL REPLIMUNE GROUP INC7.1M shares11.64%2025-12-312026-02-17

Sponsored

RARE ULTRAGENYX PHARMACEUTICAL IN3.0M shares-7.92%2025-12-312026-02-17

CRNX CRINETICS PHARMACEUTICALS IN1.4M shares54.90%2025-12-312026-02-17

ORKA ORUKA THERAPEUTICS INC2.1M shares5.78%2025-12-312026-02-17

RCKT ROCKET PHARMACEUTICALS INC17.7M shares0.00%2025-12-312026-02-17

CMPS COMPASS PATHWAYS PLC8.8M shares0.57%2025-12-312026-02-17

ISRG INTUITIVE SURGICAL INC101.2K shares-50.00%2025-12-312026-02-17

RAPT THERAPEUTICS INC RAPT THERAPEUTICS INC1.6M shares11.33%2025-12-312026-02-17

CELC CELCUITY INC550.2K sharesnew addition2025-12-312026-02-17

Sponsored

VERASTEM INC VERASTEM INC6.6M shares21.19%2025-12-312026-02-17

OBIO ORCHESTRA BIOMED HLDGS INC11.9M shares43.78%2026-02-232026-02-25

ALKS ALKERMES PLC1.7M shares0.00%2025-12-312026-02-17

OBIO 11.9M sharesnew addition2026-04-272026-04-29

CNTA CENTESSA PHARMACEUTICALS PLC1.8M shares-21.86%2025-12-312026-02-17

VSTM 7.8M sharesnew addition2025-12-312026-02-17

KOD KODIAK SCIENCES INC1.5M sharesnew addition2025-12-312026-02-17

AQST AQUESTIVE THERAPEUTICS INC6.3M shares0.00%2025-12-312026-02-17

Sponsored

ARROWHEAD PHARMACEUTICALS IN ARROWHEAD PHARMACEUTICALS IN584.7K sharesnew addition2025-12-312026-02-17

SVRA SAVARA INC6.0M sharesnew addition2025-12-312026-02-17

NGNE NEUROGENE INC1.4M shares0.00%2025-12-312026-02-17

WVE WAVE LIFE SCIENCES LTD1.4M shares50.00%2025-12-312026-02-17

JBIO JADE BIOSCIENCES INC1.4M shares0.00%2025-12-312026-02-17

EVOMMUNE INC EVOMMUNE INC1.3M sharesnew addition2025-12-312026-02-17

KYMR KYMERA THERAPEUTICS INC240.0K sharesnew addition2025-12-312026-02-17

FLGT FULGENT GENETICS INC705.0K sharesnew addition2025-12-312026-02-17

Sponsored

CGEM CULLINAN THERAPEUTICS INC1.7M shares0.00%2025-12-312026-02-17

HNGE HINGE HEALTH INC353.5K sharesnew addition2025-12-312026-02-17

BEAM BEAM THERAPEUTICS INC570.4K sharesnew addition2025-12-312026-02-17

HTFL HEARTFLOW INC495.0K shares0.00%2025-12-312026-02-17

CMPX COMPASS THERAPEUTICS INC2.5M shares0.00%2025-12-312026-02-17

TNGX TANGO THERAPEUTICS INC1.5M sharesnew addition2025-12-312026-02-17

LUMEXA IMAGING HOLDINGS INC LUMEXA IMAGING HOLDINGS INC650.0K sharesnew addition2025-12-312026-02-17

LRMR LARIMAR THERAPEUTICS INC3.1M shares0.00%2025-12-312026-02-17

Sponsored

TEM TEMPUS AI INC200.0K shares0.00%2025-12-312026-02-17

KLRS KALARIS THERAPEUTICS INC1.3M sharesnew addition2025-12-312026-02-17

TENX 651.0K sharesnew addition2025-12-312026-02-17

IQV IQVIA HLDGS INC46.0K sharesnew addition2025-12-312026-02-17

PCSC PERCEPTIVE CAP SOLUTIONS COR742.5K shares0.00%2025-12-312026-02-17

ATAI ATAI BECKLEY NV2.0M sharesnew addition2025-12-312026-02-17

ALLURION TECHNOLOGIES INC ALLURION TECHNOLOGIES INC5.9M shares0.00%2026-02-262026-03-02

CAPR CAPRICOR THERAPEUTICS INC250.0K sharesnew addition2025-12-312026-02-17

Sponsored

GPCR STRUCTURE THERAPEUTICS INC100.0K sharesnew addition2025-12-312026-02-17

SABS 1.6M sharesnew addition2025-12-312026-02-17

IVA INVENTIVA SA1.3M sharesnew addition2025-12-312026-02-17

MIST MILESTONE PHARMACEUTICALS IN2.5M shares0.00%2025-12-312026-02-17

XGN EXAGEN INC790.5K shares-53.42%2025-12-312026-02-17

TENAX THERAPEUTICS INC TENAX THERAPEUTICS INC378.3K shares0.00%2025-12-312026-02-17

CRESCENT BIOPHARMA INC. CRESCENT BIOPHARMA INC.372.9K sharesnew addition2025-12-312026-02-17

MIND MEDICINE MINDMED INC MIND MEDICINE MINDMED INC300.0K sharesnew addition2025-12-312026-02-17

Sponsored

FDMT 4D MOLECULAR THERAPEUTICS IN475.7K sharesnew addition2025-12-312026-02-17

CRVS CORVUS PHARMACEUTICALS INC447.6K shares-83.29%2025-12-312026-02-17

OMDA OMADA HEALTH INC200.0K shares0.00%2025-12-312026-02-17

MEDLINE INC MEDLINE INC70.0K sharesnew addition2025-12-312026-02-17

IRON DISC MEDICINE INC30.0K sharesnew addition2025-12-312026-02-17

IMA IMAGENEBIO INC334.4K shares0.00%2025-12-312026-02-17

ERAS ERASCA INC146.7K sharesnew addition2025-12-312026-02-17

RCKTW ROCKET PHARMACEUTICALS INC350.0K shares0.00%2025-12-312026-02-17

Sponsored

AKRO N/A sharesnew addition2025-12-312026-02-17

ALEC N/A sharesnew addition2025-12-312026-02-17

MDGL

MADRIGAL PHARMACEUTICALS INC

0.00%

Shares2.0M

Event2025-12-31

Filed2026-02-17

INSM

INSMED INC

57.00%

Shares4.8M

Event2025-12-31

Filed2026-02-17

PTCT

PTC THERAPEUTICS INC

0.00%

Shares7.7M

Event2025-12-31

Filed2026-02-17

ARGX

ARGENX SE

0.00%

Shares673.5K

Event2025-12-31

Filed2026-02-17

PTGX

PROTAGONIST THERAPEUTICS INC

-12.11%

Shares5.1M

Event2025-12-31

Filed2026-02-17

NTRA

NATERA INC

-25.00%

Shares1.5M

Event2025-12-31

Filed2026-02-17

RDNT

RADNET INC

39.88%

Shares3.9M

Event2025-12-31

Filed2026-02-17

TARS

TARSUS PHARMACEUTICALS INC

4.97%

Shares3.3M

Event2025-12-31

Filed2026-02-17

COGT

COGENT BIOSCIENCES INC

118.96%

Shares7.6M

Event2025-12-31

Filed2026-02-17

PEN

PENUMBRA INC

0.00%

Shares866.5K

Event2025-12-31

Filed2026-02-17

IRTC

IRHYTHM TECHNOLOGIES INC

New

Shares1.2M

Event2025-12-31

Filed2026-02-17

APGE

APOGEE THERAPEUTICS INC

0.00%

Shares2.7M

Event2025-12-31

Filed2026-02-17

APLS

APELLIS PHARMACEUTICALS INC

New

Shares7.7M

Event2025-12-31

Filed2026-02-17

ACAD

ACADIA PHARMACEUTICALS INC

0.00%

Shares7.1M

Event2025-12-31

Filed2026-02-17

ESTA

ESTABLISHMENT LABS HLDGS INC

0.00%

Shares2.6M

Event2025-12-31

Filed2026-02-17

STOK

STOKE THERAPEUTICS INC

8.26%

Shares5.5M

Event2025-12-31

Filed2026-02-17

RGEN

REPLIGEN CORP

New

Shares1.1M

Event2025-12-31

Filed2026-02-17

CYTK

CYTOKINETICS INC

0.00%

Shares2.7M

Event2025-12-31

Filed2026-02-17

IMCR

IMMUNOCORE HLDGS PLC

0.00%

Shares4.9M

Event2025-12-31

Filed2026-02-17

AXSM

AXSOME THERAPEUTICS INC

-20.64%

Shares888.0K

Event2025-12-31

Filed2026-02-17

GUARDANT HEALTH INC

0.00%

Shares1.5M

Event2025-12-31

Filed2026-02-17

NBIX

NEUROCRINE BIOSCIENCES INC

0.00%

Shares1.1M

Event2025-12-31

Filed2026-02-17

SYRE

SPYRE THERAPEUTICS INC

15.18%

Shares4.2M

Event2025-12-31

Filed2026-02-17

ZLAB

ZAI LAB LTD

203.71%

Shares7.0M

Event2025-12-31

Filed2026-02-17

IMTX

IMMATICS N.V

29.69%

Shares11.4M

Event2025-12-31

Filed2026-02-17

BLTE

BELITE BIO INC

128.91%

Shares715.3K

Event2025-12-31

Filed2026-02-17

URGN

UROGEN PHARMA LTD

0.00%

Shares4.5M

Event2025-12-31

Filed2026-02-17

XNCR

XENCOR INC

8.94%

Shares6.8M

Event2025-12-31

Filed2026-02-17

RAPT

New

Shares1.6M

Event2025-12-31

Filed2026-02-17

PODD

INSULET CORP

New

Shares324.6K

Event2025-12-31

Filed2026-02-17

TSHA

TAYSHA GENE THERAPIES INC

-32.67%

Shares16.4M

Event2025-12-31

Filed2026-02-17

MASI

MASIMO CORP

0.00%

Shares683.3K

Event2025-12-31

Filed2026-02-17

QURE

UNIQURE NV

-16.12%

Shares3.7M

Event2025-12-31

Filed2026-02-17

SYK

STRYKER CORPORATION

-50.00%

Shares245.0K

Event2025-12-31

Filed2026-02-17

CGON

CG ONCOLOGY INC

18.28%

Shares2.0M

Event2025-12-31

Filed2026-02-17

CSTL

CASTLE BIOSCIENCES INC

New

Shares2.1M

Event2025-12-31

Filed2026-02-17

IMVT

IMMUNOVANT INC

New

Shares3.2M

Event2025-12-31

Filed2026-02-17

BBNX

BETA BIONICS INC

-24.22%

Shares2.5M

Event2025-12-31

Filed2026-02-17

GHRS

GH RESEARCH PLC

6.54%

Shares5.9M

Event2025-12-31

Filed2026-02-17

REPL

REPLIMUNE GROUP INC

11.64%

Shares7.1M

Event2025-12-31

Filed2026-02-17

RARE

ULTRAGENYX PHARMACEUTICAL IN

-7.92%

Shares3.0M

Event2025-12-31

Filed2026-02-17

CRNX

CRINETICS PHARMACEUTICALS IN

54.90%

Shares1.4M

Event2025-12-31

Filed2026-02-17

ORKA

ORUKA THERAPEUTICS INC

5.78%

Shares2.1M

Event2025-12-31

Filed2026-02-17

RCKT

ROCKET PHARMACEUTICALS INC

0.00%

Shares17.7M

Event2025-12-31

Filed2026-02-17

CMPS

COMPASS PATHWAYS PLC

0.57%

Shares8.8M

Event2025-12-31

Filed2026-02-17

ISRG

INTUITIVE SURGICAL INC

-50.00%

Shares101.2K

Event2025-12-31

Filed2026-02-17

RAPT THERAPEUTICS INC

11.33%

Shares1.6M

Event2025-12-31

Filed2026-02-17

CELC

CELCUITY INC

New

Shares550.2K

Event2025-12-31

Filed2026-02-17

VERASTEM INC

21.19%

Shares6.6M

Event2025-12-31

Filed2026-02-17

OBIO

ORCHESTRA BIOMED HLDGS INC

43.78%

Shares11.9M

Event2026-02-23

Filed2026-02-25

ALKS

ALKERMES PLC

0.00%

Shares1.7M

Event2025-12-31

Filed2026-02-17

OBIO

New

Shares11.9M

Event2026-04-27

Filed2026-04-29

CNTA

CENTESSA PHARMACEUTICALS PLC

-21.86%

Shares1.8M

Event2025-12-31

Filed2026-02-17

VSTM

New

Shares7.8M

Event2025-12-31

Filed2026-02-17

KOD

KODIAK SCIENCES INC

New

Shares1.5M

Event2025-12-31

Filed2026-02-17

AQST

AQUESTIVE THERAPEUTICS INC

0.00%

Shares6.3M

Event2025-12-31

Filed2026-02-17

ARROWHEAD PHARMACEUTICALS IN

New

Shares584.7K

Event2025-12-31

Filed2026-02-17

SVRA

SAVARA INC

New

Shares6.0M

Event2025-12-31

Filed2026-02-17

NGNE

NEUROGENE INC

0.00%

Shares1.4M

Event2025-12-31

Filed2026-02-17

WVE

WAVE LIFE SCIENCES LTD

50.00%

Shares1.4M

Event2025-12-31

Filed2026-02-17

JBIO

JADE BIOSCIENCES INC

0.00%

Shares1.4M

Event2025-12-31

Filed2026-02-17

EVOMMUNE INC

New

Shares1.3M

Event2025-12-31

Filed2026-02-17

KYMR

KYMERA THERAPEUTICS INC

New

Shares240.0K

Event2025-12-31

Filed2026-02-17

FLGT

FULGENT GENETICS INC

New

Shares705.0K

Event2025-12-31

Filed2026-02-17

CGEM

CULLINAN THERAPEUTICS INC

0.00%

Shares1.7M

Event2025-12-31

Filed2026-02-17

HNGE

HINGE HEALTH INC

New

Shares353.5K

Event2025-12-31

Filed2026-02-17

BEAM

BEAM THERAPEUTICS INC

New

Shares570.4K

Event2025-12-31

Filed2026-02-17

HTFL

HEARTFLOW INC

0.00%

Shares495.0K

Event2025-12-31

Filed2026-02-17

CMPX

COMPASS THERAPEUTICS INC

0.00%

Shares2.5M

Event2025-12-31

Filed2026-02-17

TNGX

TANGO THERAPEUTICS INC

New

Shares1.5M

Event2025-12-31

Filed2026-02-17

LUMEXA IMAGING HOLDINGS INC

New

Shares650.0K

Event2025-12-31

Filed2026-02-17

LRMR

LARIMAR THERAPEUTICS INC

0.00%

Shares3.1M

Event2025-12-31

Filed2026-02-17

TEM

TEMPUS AI INC

0.00%

Shares200.0K

Event2025-12-31

Filed2026-02-17

KLRS

KALARIS THERAPEUTICS INC

New

Shares1.3M

Event2025-12-31

Filed2026-02-17

TENX

New

Shares651.0K

Event2025-12-31

Filed2026-02-17

IQV

IQVIA HLDGS INC

New

Shares46.0K

Event2025-12-31

Filed2026-02-17

PCSC

PERCEPTIVE CAP SOLUTIONS COR

0.00%

Shares742.5K

Event2025-12-31

Filed2026-02-17

ATAI

ATAI BECKLEY NV

New

Shares2.0M

Event2025-12-31

Filed2026-02-17

ALLURION TECHNOLOGIES INC

0.00%

Shares5.9M

Event2026-02-26

Filed2026-03-02

CAPR

CAPRICOR THERAPEUTICS INC

New

Shares250.0K

Event2025-12-31

Filed2026-02-17

GPCR

STRUCTURE THERAPEUTICS INC

New

Shares100.0K

Event2025-12-31

Filed2026-02-17

SABS

New

Shares1.6M

Event2025-12-31

Filed2026-02-17

IVA

INVENTIVA SA

New

Shares1.3M

Event2025-12-31

Filed2026-02-17

MIST

MILESTONE PHARMACEUTICALS IN

0.00%

Shares2.5M

Event2025-12-31

Filed2026-02-17

XGN

EXAGEN INC

-53.42%

Shares790.5K

Event2025-12-31

Filed2026-02-17

TENAX THERAPEUTICS INC

0.00%

Shares378.3K

Event2025-12-31

Filed2026-02-17

CRESCENT BIOPHARMA INC.

New

Shares372.9K

Event2025-12-31

Filed2026-02-17

MIND MEDICINE MINDMED INC

New

Shares300.0K

Event2025-12-31

Filed2026-02-17

FDMT

4D MOLECULAR THERAPEUTICS IN

New

Shares475.7K

Event2025-12-31

Filed2026-02-17

CRVS

CORVUS PHARMACEUTICALS INC

-83.29%

Shares447.6K

Event2025-12-31

Filed2026-02-17

OMDA

OMADA HEALTH INC

0.00%

Shares200.0K

Event2025-12-31

Filed2026-02-17

MEDLINE INC

New

Shares70.0K

Event2025-12-31

Filed2026-02-17

IRON

DISC MEDICINE INC

New

Shares30.0K

Event2025-12-31

Filed2026-02-17

IMA

IMAGENEBIO INC

0.00%

Shares334.4K

Event2025-12-31

Filed2026-02-17

ERAS

ERASCA INC

New

Shares146.7K

Event2025-12-31

Filed2026-02-17

RCKTW

ROCKET PHARMACEUTICALS INC

0.00%

Shares350.0K

Event2025-12-31

Filed2026-02-17

AKRO

New

SharesN/A

Event2025-12-31

Filed2026-02-17

ALEC

New

SharesN/A

Event2025-12-31

Filed2026-02-17

Call Option Holdings

No call option holdings data available

Put Option Holdings

No put option holdings data available