The Analysis of ORBIMED ADVISORS LLC's Holdings & P&L


Currently, ORBIMED ADVISORS LLC holds 109 types of securities in its portfolio with a total value $5.1B. In the most recent quarter, they have increased their positions in ACET (+10.0M shares, valued at $68.4M), BMY (+775.0K shares, valued at $41.8M), PFE (+1.7M shares, valued at $41.2M); decreased their positions in TERN (-5.4M shares, valued at $218.6M), RNA (-1.0M shares, valued at $73.5M), EXAS (-642.9K shares, valued at $65.3M); initiated new positions in BMY (+775.0K shares, valued at $41.8M), PFE (+1.7M shares, valued at $41.2M), ELV (+99.1K shares, valued at $34.7M); completely sold out of PMVP (previously valued at $6.2M).


1M P&L
-25.5M-0.56%
3M P&L
-187.5M-3.99%
HY P&L
+439.0M+10.78%

P&L figures are estimated based on reported 13F stock holdings and market price changes. They are approximations and may not reflect actual fund performance. Stock split events may also affect the accuracy of these calculations, and we cannot guarantee that all splits have been fully accounted for.

Top Holding Treemap

Top Industries by Value

1Biotechnology3.3B
67.9%
2Medical Devices570.3M
11.8%
3Drug Manufacturers - General406.7M
8.4%

Top Industries by Stock Count

1Biotechnology72 stocks
76.6%
2Medical Devices6 stocks
6.4%
3Drug Manufacturers - Specialty & Generic5 stocks
5.3%
Stock Holdings
EWTX
EDGEWISE THERAPEUTICS INC
0.00%
Shares15.5M
Event2025-12-31
Filed2026-02-17
LLY
ELI LILLY & CO
0.00%
Shares301.2K
Event2025-12-31
Filed2026-02-17
BSX
BOSTON SCIENTIFIC CORP
-0.41%
Shares2.4M
Event2025-12-31
Filed2026-02-17
CRVS
CORVUS PHARMACEUTICALS INC
20.15%
Shares8.6M
Event2026-01-23
Filed2026-01-27
SVA
SINOVAC BIOTECH LTD
0.00%
Shares2.7M
Event2025-12-31
Filed2026-02-17
EW
EDWARDS LIFESCIENCES CORP
9.44%
Shares1.8M
Event2025-12-31
Filed2026-02-17
UPB
UPSTREAM BIO INC
0.00%
Shares5.7M
Event2025-12-31
Filed2026-02-17
ISRG
INTUITIVE SURGICAL INC
-8.29%
Shares263.4K
Event2025-12-31
Filed2026-02-17
SION
SIONNA THERAPEUTICS INC
-3.87%
Shares3.6M
Event2025-12-31
Filed2026-02-17
MBX
MBX BIOSCIENCES INC
-7.56%
Shares3.6M
Event2026-02-05
Filed2026-02-11
ARGX
ARGENX SE
-15.26%
Shares146.0K
Event2025-12-31
Filed2026-02-17
ELVN
ENLIVEN THERAPEUTICS INC
0.00%
Shares8.0M
Event2025-12-31
Filed2026-02-17
ALNY
ALNYLAM PHARMACEUTICALS INC
-4.24%
Shares288.8K
Event2025-12-31
Filed2026-02-17
SYK
STRYKER CORPORATION
-9.52%
Shares325.0K
Event2025-12-31
Filed2026-02-17
SPRY
ARS PHARMACEUTICALS INC
0.00%
Shares8.3M
Event2025-12-31
Filed2026-02-17
TERN
TERNS PHARMACEUTICALS INC
-71.53%
Shares2.2M
Event2025-12-31
Filed2026-02-17
IRON
DISC MEDICINE INC
-24.56%
Shares1.1M
Event2025-12-31
Filed2026-02-17
CAI
CARIS LIFE SCIENCES INC
2.67%
Shares3.1M
Event2025-12-31
Filed2026-02-17
NTRA
NATERA INC
-14.79%
Shares365.8K
Event2025-12-31
Filed2026-02-17
CMPX
COMPASS THERAPEUTICS INC
0.00%
Shares15.2M
Event2025-12-31
Filed2026-02-17
GPCR
STRUCTURE THERAPEUTICS INC
1.98%
Shares1.2M
Event2025-12-31
Filed2026-02-17
DHR
DANAHER CORPORATION
13.95%
Shares299.8K
Event2025-12-31
Filed2026-02-17
CGON
CG ONCOLOGY INC
-12.18%
Shares1.5M
Event2025-12-31
Filed2026-02-17
APLS
APELLIS PHARMACEUTICALS INC
4.58%
Shares2.4M
Event2025-12-31
Filed2026-02-17
AVBP
ARRIVENT BIOPHARMA INC
0.00%
Shares3.0M
Event2025-12-31
Filed2026-02-17
THE CIGNA GROUP
THE CIGNA GROUP
25.92%
Shares205.0K
Event2025-12-31
Filed2026-02-17
335.86%
Shares12.9M
Event2026-04-21
Filed2026-04-23
RAPT THERAPEUTICS INC
RAPT THERAPEUTICS INC
51.19%
Shares1.6M
Event2025-12-31
Filed2026-02-17
UTHR
UNITED THERAPEUTICS CORP DEL
-8.44%
Shares105.2K
Event2025-12-31
Filed2026-02-17
ABVX
ABIVAX SA
-3.18%
Shares367.9K
Event2025-12-31
Filed2026-02-17
ROIV
ROIVANT SCIENCES LTD
-19.30%
Shares2.2M
Event2025-12-31
Filed2026-02-17
CRNX
CRINETICS PHARMACEUTICALS IN
-9.10%
Shares999.0K
Event2025-12-31
Filed2026-02-17
AXSM
AXSOME THERAPEUTICS INC
-52.40%
Shares253.1K
Event2025-12-31
Filed2026-02-17
EYPT
EYEPOINT INC
37.43%
Shares2.5M
Event2025-12-31
Filed2026-02-17
RNA
AVIDITY BIOSCIENCES INC
-62.20%
Shares619.5K
Event2025-12-31
Filed2026-02-17
NBIX
NEUROCRINE BIOSCIENCES INC
-11.14%
Shares314.2K
Event2025-12-31
Filed2026-02-17
DYN
DYNE THERAPEUTICS INC
-4.84%
Shares2.2M
Event2025-12-31
Filed2026-02-17
BMY
BRISTOL-MYERS SQUIBB CO
New
Shares775.0K
Event2025-12-31
Filed2026-02-17
PFE
PFIZER INC
New
Shares1.7M
Event2025-12-31
Filed2026-02-17
TRVI
TREVI THERAPEUTICS INC
-3.56%
Shares3.2M
Event2025-12-31
Filed2026-02-17
NPCE
NEUROPACE INC
-7.95%
Shares2.4M
Event2025-12-31
Filed2026-02-17
ASND
ASCENDIS PHARMA A/S
-10.38%
Shares172.0K
Event2025-12-31
Filed2026-02-17
EXAS
EXACT SCIENCES CORP
-64.64%
Shares351.7K
Event2025-12-31
Filed2026-02-17
MLYS
MINERALYS THERAPEUTICS INC
-33.28%
Shares980.4K
Event2025-12-31
Filed2026-02-17
ELV
ELEVANCE HEALTH INC FORMERLY
New
Shares99.1K
Event2025-12-31
Filed2026-02-17
FORTE BIOSCIENCES INC
FORTE BIOSCIENCES INC
0.00%
Shares1.2M
Event2025-12-31
Filed2026-02-17
PRLD
PRELUDE THERAPEUTICS INC
0.00%
Shares10.9M
Event2025-12-31
Filed2026-02-17
CYBN
CYBIN INC
New
Shares3.8M
Event2025-12-31
Filed2026-02-17
ORIC
ORIC PHARMACEUTICALS INC
0.00%
Shares3.6M
Event2025-12-31
Filed2026-02-17
KRYS
KRYSTAL BIOTECH INC
16.60%
Shares119.8K
Event2025-12-31
Filed2026-02-17
PRAXIS PRECISION MEDICINES I
PRAXIS PRECISION MEDICINES I
New
Shares94.5K
Event2025-12-31
Filed2026-02-17
JANX
JANUX THERAPEUTICS INC
10.66%
Shares2.0M
Event2025-12-31
Filed2026-02-17
TMO
THERMO FISHER SCIENTIFIC INC
0.00%
Shares46.5K
Event2025-12-31
Filed2026-02-17
BRKR
BRUKER CORP
New
Shares555.8K
Event2025-12-31
Filed2026-02-17
RYTM
RHYTHM PHARMACEUTICALS INC
11.46%
Shares239.8K
Event2025-12-31
Filed2026-02-17
STTK
SHATTUCK LABS INC
0.00%
Shares6.3M
Event2025-12-31
Filed2026-02-17
ESPR
ESPERION THERAPEUTICS INC NE
New
Shares6.0M
Event2025-12-31
Filed2026-02-17
AVALO THERAPEUTICS INC
AVALO THERAPEUTICS INC
-12.01%
Shares1.2M
Event2025-12-31
Filed2026-02-17
LXEO
LEXEO THERAPEUTICS INC
New
Shares2.1M
Event2025-12-31
Filed2026-02-17
ADCT
ADC THERAPEUTICS SA
-1.43%
Shares5.8M
Event2025-12-31
Filed2026-02-17
URGN
UROGEN PHARMA LTD
27.07%
Shares875.5K
Event2025-12-31
Filed2026-02-17
IMAGENEBIO INC
IMAGENEBIO INC
0.00%
Shares6.2M
Event2025-12-31
Filed2026-02-17
XENE
XENON PHARMACEUTICALS INC
6.58%
Shares447.2K
Event2025-12-31
Filed2026-02-17
New
Shares1.2M
Event2025-12-31
Filed2026-02-17
BTSG
BRIGHTSPRING HEALTH SVCS INC
85.18%
Shares488.5K
Event2025-12-31
Filed2026-02-17
VERA
VERA THERAPEUTICS INC
New
Shares353.5K
Event2025-12-31
Filed2026-02-17
QURE
UNIQURE NV
60.83%
Shares737.4K
Event2025-12-31
Filed2026-02-17
MIND MEDICINE MINDMED INC
MIND MEDICINE MINDMED INC
233.50%
Shares1.2M
Event2025-12-31
Filed2026-02-17
KROS
KEROS THERAPEUTICS INC
-21.06%
Shares804.2K
Event2025-12-31
Filed2026-02-17
QTTB
Q32 BIO INC
0.00%
Shares2.3M
Event2026-02-18
Filed2026-03-12
CARL
CARLSMED INC
0.00%
Shares1.3M
Event2025-12-31
Filed2026-02-17
CTMX
CYTOMX THERAPEUTICS INC
-58.33%
Shares3.5M
Event2025-12-31
Filed2026-02-17
VIR
VIR BIOTECHNOLOGY INC
0.00%
Shares2.4M
Event2025-12-31
Filed2026-02-17
BCRX
BIOCRYST PHARMACEUTICALS INC
93.21%
Shares1.7M
Event2025-12-31
Filed2026-02-17
COGT
COGENT BIOSCIENCES INC
New
Shares371.0K
Event2025-12-31
Filed2026-02-17
CORBUS PHARMACEUTICALS HLDGS
CORBUS PHARMACEUTICALS HLDGS
36.25%
Shares1.6M
Event2025-12-31
Filed2026-02-17
TARS
TARSUS PHARMACEUTICALS INC
-21.98%
Shares154.4K
Event2025-12-31
Filed2026-02-17
RLMD
RELMADA THERAPEUTICS INC
New
Shares2.6M
Event2025-12-31
Filed2026-02-17
TECX
TECTONIC THERAPEUTIC INC
New
Shares574.6K
Event2025-12-31
Filed2026-02-17
ALMS
ALUMIS INC
-42.76%
Shares1.1M
Event2025-12-31
Filed2026-02-17
BIOA
BIOAGE LABS INC
0.00%
Shares790.9K
Event2025-12-31
Filed2026-02-17
FOLD
AMICUS THERAPEUTICS INC
-55.64%
Shares729.9K
Event2025-12-31
Filed2026-02-17
WHWK
WHITEHAWK THERAPEUTICS INC
0.00%
Shares4.2M
Event2025-12-31
Filed2026-02-17
ADICET BIO INC
ADICET BIO INC
New
Shares1.0M
Event2025-12-31
Filed2026-02-17
RPTX
REPARE THERAPEUTICS INC
0.00%
Shares3.3M
Event2025-12-31
Filed2026-02-17
CELC
CELCUITY INC
1.96%
Shares85.7K
Event2025-12-31
Filed2026-02-17
JBIO
JADE BIOSCIENCES INC
0.00%
Shares531.2K
Event2025-12-31
Filed2026-02-17
KINIKSA PHARMACEUTICALS INTL
KINIKSA PHARMACEUTICALS INTL
New
Shares187.2K
Event2025-12-31
Filed2026-02-17
KALV
KALVISTA PHARMACEUTICALS INC
New
Shares382.4K
Event2025-12-31
Filed2026-02-17
PHVS
PHARVARIS N V
New
Shares205.4K
Event2025-12-31
Filed2026-02-17
INSPIREMD INC
INSPIREMD INC
46.87%
Shares3.1M
Event2025-12-31
Filed2026-02-17
New
Shares3.1M
Event2025-12-31
Filed2026-02-17
INSM
INSMED INC
88.72%
Shares25.4K
Event2025-12-31
Filed2026-02-17
PALISADE BIO INC
PALISADE BIO INC
New
Shares1.9M
Event2025-12-31
Filed2026-02-17
BCAX
BICARA THERAPEUTICS INC
New
Shares209.1K
Event2025-12-31
Filed2026-02-17
CGEM
CULLINAN THERAPEUTICS INC
-85.97%
Shares270.0K
Event2025-12-31
Filed2026-02-17
CCCC
C4 THERAPEUTICS INC
-73.16%
Shares1.4M
Event2025-12-31
Filed2026-02-17
IMA
IMAGENEBIO INC
0.00%
Shares378.6K
Event2025-12-31
Filed2026-02-17
ANRO
ALTO NEUROSCIENCE INC
-50.00%
Shares125.0K
Event2025-12-31
Filed2026-02-17
RVMD
REVOLUTION MEDICINES INC
New
Shares25.9K
Event2025-12-31
Filed2026-02-17
VISTAGEN THERAPEUTICS INC
VISTAGEN THERAPEUTICS INC
0.00%
Shares3.1M
Event2025-12-31
Filed2026-02-17
OCUL
OCULAR THERAPEUTIX INC
New
Shares157.3K
Event2025-12-31
Filed2026-02-17
PTGX
PROTAGONIST THERAPEUTICS INC
New
Shares21.7K
Event2025-12-31
Filed2026-02-17
PTCT
PTC THERAPEUTICS INC
New
Shares23.2K
Event2025-12-31
Filed2026-02-17
COGENT BIOSCIENCES INC
COGENT BIOSCIENCES INC
New
Shares1.0M
Event2025-12-31
Filed2026-02-17
MAPLIGHT THERAPEUTICS INC
MAPLIGHT THERAPEUTICS INC
New
Shares56.0K
Event2025-12-31
Filed2026-02-17
New
Shares1.4M
Event2025-12-31
Filed2026-02-17
TRAW
TRAWS PHARMA INC
0.00%
Shares605.5K
Event2025-12-31
Filed2026-02-17
PMVP
PMV PHARMACEUTICALS INC
Sold all
SharesN/A
Event2026-03-02
Filed2026-03-04

Call Option Holdings
EW Call
EDWARDS LIFESCIENCES CORP
New
Shares150.0K
Event2025-12-31
Filed2026-02-17
VISTAGEN THERAPEUTICS INC Call
VISTAGEN THERAPEUTICS INC
0.00%
Shares45.2K
Event2025-12-31
Filed2026-02-17

Put Option Holdings
No put option holdings data available